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Drug: Metformin

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Total 7110 results found since Jan 2013.

Aberrant Endoplasmic Reticulum Stress in Vascular Smooth Muscle Increases Vascular Contractility and Blood Pressure in Mice Deficient of AMP-Activated Protein Kinase-α2 In Vivo.
CONCLUSIONS: We conclude that ER stress increases vascular smooth muscle contractility resulting in high blood pressure, and AMP-activated protein kinase activation mitigates high blood pressure through the suppression of ER stress in vivo. PMID: 23288166 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 3, 2013 Category: Cardiology Authors: Liang B, Wang S, Wang Q, Zhang W, Viollet B, Zhu Y, Zou MH Tags: Arterioscler Thromb Vasc Biol Source Type: research

Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase.
Abstract To explore the hypothesis that DPP-IV are involved in the diabetes-induced vascular damage, we assessed the vascular effects of chronic administration of Saxagliptin (Saxa) or Metformin (Met) in db/db mice, a model of type 2 diabetes, evaluating vascular structure and endothelial function in mesenteric small arteries. The increases in media/lm and media cross sectional area were prevented by Saxa. In db/db, the blunted response to acetylcholine was only marginally affected by L-NAME (NO-synthase inhibitor), improved by SC-560 (Cyclooxygenase-1 inhibitor) or SQ-29,548 (thromboxane receptor antagonist), and...
Source: Vascular Pharmacology - October 6, 2015 Category: Drugs & Pharmacology Authors: Solini A, Rossi C, Duranti E, Taddei S, Natali A, Virdis A Tags: Vascul Pharmacol Source Type: research

GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1
CONCLUSIONS: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.PMID:37586054 | DOI:10.1161/ATVBAHA.123.319476
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 16, 2023 Category: Cardiology Authors: Caleb A Padgett R óbert K Bátori Andrew C Speese Cody L Rosewater Weston B Bush Cassandra C Derella Stephen B Haigh Hunter G Sellers Zachary L Corley Madison A West James D Mintz Brittany B Ange Ryan A Harris Michael W Brands David J R Fulton David W St Source Type: research

Increased fractalkine and vascular dysfunction in obesity and in type 2 diabetes. Effects of oral antidiabetic treatment.
Abstract Activation of fractalkine and other chemokines plays an important role in atherogenesis and, in conjunction with endothelial dysfunction, promotes premature vascular damage in obesity and diabetes. We hypothesized that increased circulating fractalkine coexists with impaired vasomotor function in metabolically healthy or unhealthy obesity, and that treatment with antidiabetic drugs may impact these abnormalities in type 2 diabetes. Compared to lean subjects, in both obese groups the vasodilator responses to acetylcholine and sodium nitroprusside were impaired (both P < .001); ETA-receptor blockade ...
Source: Vascular Pharmacology - March 25, 2020 Category: Drugs & Pharmacology Authors: Schinzari F, Tesauro M, Campia U, Cardillo C Tags: Vascul Pharmacol Source Type: research

Metformin inhibited homocysteine-induced upregulation of endothelin receptors through the Sirt1/NF- κB signaling pathway in vascular smooth muscle cells.
In conclusion, these data demonstrated that Met inhibited the Hcy-induced increase in endothelin receptor expression by activating Sirt1 and then inhibiting NF-κB in VSMCs. These findings may provide insights into the mechanism underlying of Met-treated cardiovascular diseases induced by Hcy. PMID: 31678650 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - October 30, 2019 Category: Drugs & Pharmacology Authors: Chen Y, Su X, Qin Q, Yu Y, Jia M, Kong L, Zhang H, Li H Tags: Vascul Pharmacol Source Type: research

Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway.
PMID: 26772768 [PubMed - as supplied by publisher]
Source: Vascular Pharmacology - January 7, 2016 Category: Drugs & Pharmacology Authors: Zhang X, Xiao J, Li R, Qin X, Wang F, Mao Y, Liang W, Sheng X, Guo M, Song Y, Ji X Tags: Vascul Pharmacol Source Type: research

Metformin does not reduce inflammation in diabetics with abdominal aortic aneurysm or at high risk of abdominal aortic aneurysm formation.
Conclusion Metformin in diabetics at-risk for abdominal aortic aneurysm or diagnosed with abdominal aortic aneurysm does not seem to alter the peripheral inflammatory environment. PMID: 29871586 [PubMed - as supplied by publisher]
Source: Vascular - January 1, 2018 Category: Surgery Authors: Wang SK, Green LA, Gutwein AR, Kenyon B, Motaganahalli RL, Fajardo A, Gupta AK, Murphy MP Tags: Vascular Source Type: research

Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux
CONCLUSIONS: Metformin prevents VSMC and vascular senescence by promoting autolysosome formation.PMID:36328749 | DOI:10.1016/j.jare.2021.12.009
Source: Cell Research - November 3, 2022 Category: Cytology Authors: Shi Tai Jiaxing Sun Yuying Zhou Zhaowei Zhu Yuhu He Mingxian Chen Hui Yang Yichao Xiao Tao Tu Liang Tang Xuping Li Jianping Zeng Xilong Zheng Shenghua Zhou Source Type: research

Metformin alleviates monoamine oxidase-related vascular oxidative stress and endothelial dysfunction in rats with diet-induced obesity
In conclusion, METF elicited vascular protective effects via the mitigation of MAO-related oxidative stress in the rat model of diet-induced obesity.PMID:34216348 | DOI:10.1007/s11010-021-04194-2
Source: Molecular and Cellular Biochemistry - July 3, 2021 Category: Biochemistry Authors: Loredana N Ionic ă Laura Gai ță Anca M B înă Raluca So șdean Rodica Lighezan Alexandra Sima Daniel Mali ța Octavian M Cre țu Ovidiu Burlacu Danina M Muntean Adrian Sturza Source Type: research